Condition
Rotator Cuff
Used as an adjunct during shoulder tendon repair in some studies.
Quick summary
- • Main outcomes are re-tear rate and function scores
Overview
Rotator cuff tears have a notable post-surgical re-tear rate, motivating cell-augmentation research.
Mechanisms studied
Studied at the tendon-to-bone healing interface.
Human research
Some cohort studies report lower re-tear rates, but confirmation is needed.
Safety
Reported adverse events are mostly local — swelling, pain, or bruising at the harvest and injection sites. Infection and cell-processing quality remain the key risks to monitor.
Evidence limitations
Existing studies are limited by sample size, methodology, and follow-up, and SVF preparation differs substantially between centres, making cross-study comparison difficult.
Latest PubMed research
229 indexed studies for this condition · auto-updated 17 August 2026
- Level ASystematic ReviewEurope PMC
Comparing Regenerative Biologics and Standard Pharmacotherapy for Chronic Rotator Cuff Tendinopathy: A Study of PRP, Cell-Based, and Peptide Interventions
Systematic Review on Tendon Injury, Rotator Cuff, Shoulder Pain, Chronic Inflammation, published in J Orthop Sports Med (2026) — summary generated from the PubMed abstract.
- 2026
J Orthop Sports Med - Level AMeta-analysisEurope PMC
Surgical vs. non-surgical therapy for partial tears of the rotator cuff: a systematic review and meta-analysis of pooled studies with indirect comparison
Meta-analysis with a reported sample of 818 on Tendon Injury, Rotator Cuff, Shoulder Pain, published in BMC Musculoskelet Disord (2026) — summary generated from the PubMed abstract.
- 2026
- n = 818
BMC Musculoskelet Disord - Level AMeta-analysisEurope PMC
Comparison of nonsurgical treatment approaches for partial rotator cuff tears: a systematic review and meta-analysis
Meta-analysis with a reported sample of 137 on Rotator Cuff, Shoulder Pain, published in JSES Rev Rep Tech (2026) — summary generated from the PubMed abstract.
- 2026
- n = 137
JSES Rev Rep Tech - Level ASystematic ReviewPubMed
The role of injections of mesenchymal stem cells as an augmentation tool in rotator cuff repair: a systematic review.
Systematic Review with a reported sample of 5 on Tendon Injury, Rotator Cuff, published in JSES Rev Rep Tech (2025) — summary generated from the PubMed abstract.
- 2025
- n = 5
JSES Rev Rep Tech - Level ASystematic ReviewPubMed
Poor consideration of tissue loading in randomised trials of MSC interventions for tendon pathology: A systematic review using the TIDieR framework.
Systematic Review on Tendon Injury, Rotator Cuff, published in J Exp Orthop (2025) — summary generated from the PubMed abstract.
- 2025
J Exp Orthop - Level AMeta-analysisEurope PMC
Combined arthroscopic rotator cuff repair with mesenchymal stem cell augmentation shows similar functional outcomes but a higher structural integrity rate compared with isolated repair: a meta-analysis of comparative stu
Meta-analysis with a reported sample of 415 on Tendon Injury, Rotator Cuff, published in JSES Int (2025) — summary generated from the PubMed abstract.
- 2025
- n = 415
JSES Int
Last updated: 2026-06-18 · arisa-w