Condition
Skin Aging
Usually studied alongside facial fat grafting.
Quick summary
- • Outcomes assessed by photography and skin instruments
- • Participant satisfaction is a common measure
Overview
Skin ageing involves collagen loss and reduced subdermal volume.
Mechanisms studied
Dermal thickness and elasticity are studied.
Human research
Most studies are small with 6–12 months of follow-up.
Safety
Reported adverse events are mostly local — swelling, pain, or bruising at the harvest and injection sites. Infection and cell-processing quality remain the key risks to monitor.
Evidence limitations
Existing studies are limited by sample size, methodology, and follow-up, and SVF preparation differs substantially between centres, making cross-study comparison difficult.
Related research
- Level BMeta-analysis
Stromal Vascular Fraction-Assisted Fat Grafting: A Systematic Review and Meta-analysis of Clinical Outcomes
Meta-analysis comparing SVF-enriched fat grafting with conventional technique, assessing graft retention and safety.
- 2026
- Saudi Arabia
- Level BMeta-analysis
Cell-assisted lipotransfer: Friend or foe in fat grafting? Systematic review and meta-analysis
Included 25 studies with 696 patients; fat survival rate was significantly higher with cell-assisted lipotransfer than conventional grafting.
- 2018
- France
- n = 696
- Level BMeta-analysis
Efficacy and Safety of Cell-Assisted Lipotransfer: A Systematic Review and Meta-Analysis
Pooled 17 articles covering 387 cases to estimate fat survival rate along with complication and reoperation incidence.
- 2016
- China
- n = 387
- Level CSystematic Review
Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports
Reviewed 57 CAL studies focusing on drawbacks and risks such as graft liquefaction/resorption and the absence of standardised guidelines.
- 2016
- China
- Level DCase Series
Nanofat grafting: basic research and clinical applications
Reports 67 clinical cases of nanofat for superficial rhytides, scars and dark lower eyelids, plus analysis of the cellular content of processed fat.
- 2013
- Belgium
- n = 67
Latest PubMed research
489 indexed studies for this condition · auto-updated 17 August 2026
- Level ASystematic ReviewPubMed
Regeneration in Aesthetic Medicine: Mechanisms, Evidence, and Clinical Boundaries.
Systematic Review on Skin Aging, Immune Modulation, published in J Cosmet Dermatol (2026) — summary generated from the PubMed abstract.
- 2026
J Cosmet Dermatol - Level ASystematic ReviewEurope PMC
Efficacy of Exosome-Based Therapies for Skin Rejuvenation: A Systematic Review of Human Studies
Systematic Review on Neuroinflammation, Skin Aging, published in Cureus (2026) — summary generated from the PubMed abstract.
- 2026
Cureus - Level ASystematic ReviewPubMed
Exosomes in Skin Rejuvenation: Systematic Review of Anti-Aging Effects and Clinical Applications.
Systematic Review on Chronic Wound, Skin Aging, published in Dermatol Pract Concept (2026) — summary generated from the PubMed abstract.
- 2026
Dermatol Pract Concept - Level ASystematic ReviewEurope PMC
Cutaneous lymphatics and skin diseases: mechanisms, imaging modalities, and future therapeutic strategies
Systematic Review on Skin Aging, Chronic Inflammation, Autoimmune Research, published in Front Physiol (2026) — summary generated from the PubMed abstract.
- 2026
Front Physiol - Level ASystematic ReviewEurope PMC
Autolougous platelet concentrates in esthetic medicine
Systematic Review on Scar, Skin Aging, Facial Rejuvenation, Hair Regeneration, published in Periodontol 2000 (2025) — summary generated from the PubMed abstract.
- 2025
Periodontol 200016 citations - Level ASystematic ReviewPubMed
Hand Rejuvenation Using Autologous Fat Grafting: A Systematic Review of Recommended Doses, Complications, and Patient Satisfaction.
Systematic Review with a reported sample of 303 on Skin Aging, published in Aesthetic Plast Surg (2025) — summary generated from the PubMed abstract.
- 2025
- n = 303
Aesthetic Plast Surg
Last updated: 2026-06-18 · arisa-w