Condition
Skin Aging
Usually studied alongside facial fat grafting.
Quick summary
- • Outcomes assessed by photography and skin instruments
- • Participant satisfaction is a common measure
Overview
Skin ageing involves collagen loss and reduced subdermal volume.
Mechanisms studied
Dermal thickness and elasticity are studied.
Human research
Most studies are small with 6–12 months of follow-up.
Safety
Reported adverse events are mostly local — swelling, pain, or bruising at the harvest and injection sites. Infection and cell-processing quality remain the key risks to monitor.
Evidence limitations
Existing studies are limited by sample size, methodology, and follow-up, and SVF preparation differs substantially between centres, making cross-study comparison difficult.
Related research
- Level BMeta-analysis
Stromal Vascular Fraction-Assisted Fat Grafting: A Systematic Review and Meta-analysis of Clinical Outcomes
Meta-analysis comparing SVF-enriched fat grafting with conventional technique, assessing graft retention and safety.
- 2026
- Saudi Arabia
- Level BMeta-analysis
Cell-assisted lipotransfer: Friend or foe in fat grafting? Systematic review and meta-analysis
Included 25 studies with 696 patients; fat survival rate was significantly higher with cell-assisted lipotransfer than conventional grafting.
- 2018
- France
- n = 696
- Level BMeta-analysis
Efficacy and Safety of Cell-Assisted Lipotransfer: A Systematic Review and Meta-Analysis
Pooled 17 articles covering 387 cases to estimate fat survival rate along with complication and reoperation incidence.
- 2016
- China
- n = 387
- Level CSystematic Review
Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports
Reviewed 57 CAL studies focusing on drawbacks and risks such as graft liquefaction/resorption and the absence of standardised guidelines.
- 2016
- China
- Level DCase Series
Nanofat grafting: basic research and clinical applications
Reports 67 clinical cases of nanofat for superficial rhytides, scars and dark lower eyelids, plus analysis of the cellular content of processed fat.
- 2013
- Belgium
- n = 67
Last updated: 2026-06-18 · arisa-w