3D-Bioprinted Oil-Based Hydrogels: A Sustainable Approach for Bone and Dental Regeneration
Masri S., Mohd N., Abu Kasim NH., Razali M.
Narrative Review, published in Int J Mol Sci (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Int J Mol Sci (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40332025
- PMCID
- PMC12026678
- DOI
- 10.3390/ijms26083510
- Citations
- 5
Abstract (original English)
Recent advancements in 3D bioprinting technology have transformed the development of complex tissue scaffolds, offering significant potential for applications in bone and dental regenerative medicine. Oil-based hydrogels have garnered considerable interest owing to their tunable mechanical properties, biocompatibility, and ability to facilitate cell adhesion, proliferation, and differentiation. This review provides an in-depth review of recent research regarding the utilization of oil-based hydrogels in bone and dental tissue development, focusing on the 3D bioprinting strategies. The review investigates the biological efficacy of the diverse oils used in hydrogel formulations, as well as their physicochemical properties, in promoting osteogenesis and dental tissue regeneration. Significant results from both in vitro and in vivo research are examined, emphasizing their capacity to sustain biological functions and promote tissue regeneration. Challenges such as hydrogel stability, printability, and cytotoxicity efficiency are thoroughly examined, along with strategies to improve these materials for translational and clinical applications. This study highlights the revolutionary potential of oil-based hydrogels in enhancing bone and dental regenerative medicine, providing insights into their current status, as well as future research and development pathways.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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