3D collagen nanofiber scaffold with adipose derived stem cells for functional adipose tissue regeneration.
Zhang L., Xue Y., Mu D., Chen S., Wu G., Yang Z.
Animal Study, published in Sci Rep (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Sci Rep (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40593981
- PMCID
- PMC12219823
- DOI
- 10.1038/s41598-025-04763-1
- Citations
- 2
Abstract (original English)
Adipose tissue engineering offers a promising approach for breast reconstruction, yet achieving efficient adipose regeneration remains challenging due to poor cell survival and tissue integration. Hence, we developed a three-dimensional (3D) electrospun collagen nanofiber scaffold integrated with adipose-derived mesenchymal stem cells (ADSCs), designed to enhance adipose tissue regeneration by providing a biomimetic extracellular matrix environment. The incorporation of collagen nanofibers enhances cell adhesion and extracellular matrix remodeling, further promoting adipogenic differentiation. Compared to conventional two-dimensional (2D) culture, ADSCs seeded on the scaffold exhibit significantly improved viability and lipid accumulation. In vivo implantation in a rat model demonstrated that the COL-ADSCs composite scaffold increased subcutaneous fat thickness from 2.69 ± 0.10 mm to 3.37 ± 0.11 mm over four weeks, while also promoting collagen remodeling and angiogenesis, as confirmed by CD31-positive staining. Despite these promising outcomes, this study is limited to a small animal model, and further validation in large animal models and clinical settings is necessary. These findings indicate that the COL-ADSCs composite scaffold provides a biomimetic microenvironment that supports ADSC adhesion, differentiation, and tissue remodeling, highlighting its potential as a clinica
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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