3D-printed Laponite/alginate hydrogel-based suppositories as innovative platforms for AT-MSC secretome delivery in IBD treatment.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The secretome of Mesenchymal Stromal Cells (MSCs) has demonstrated effectiveness in the treatment of Inflammatory Bowel Disease (IBD), offering a safer and more predictable alternative to the direct administration of MSCs. While parenteral administration is common, rectal delivery of the secretome provides targeted treatment for localized conditions such as ulcerative colitis and proctitis. Alginate-Laponite 3D-printed suppositories (Alg-Lap 3DPS) have shown a remarkable versatility in their ability to encapsulate and deliver therapeutic agents during previous studies. These formulations are also adaptable in the release of molecules with different physicochemical properties, and a Bovine Serum Albumin (BSA) displacement strategy has been proposed in order to promote their disintegration and controlled release. As such, these 3DPS formulations represent highly versatile pharmaceutical forms, enabling the rectal delivery of diverse molecules with controlled release characteristics. In this study, we combined the therapeutic potential of Adipose tissue derived-MSCs-secretome (AT-S) with the versatility and efficacy of Alg-Lap 3DPS. Herein, we demonstrate that these formulations are well-suited for the encapsulation and release of AT-S, confirming their ability to release bioactive factors from AT-S such as Galectin-9 upon applying the displacement strategy. Moreover, we validate

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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