3D-Printed Scaffolds for Ear Reconstruction Using Decellularized Human Cartilage-Derived Bioink and Polycaprolactone.
Um JH., Park JH., Kim TH., Park SH., Mun J., Kang EH.
Prospective Study, published in ACS Biomater Sci Eng (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- ACS Biomater Sci Eng (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40312956
- DOI
- 10.1021/acsbiomaterials.4c01990
Abstract (original English)
Reconstructing auricular tissue is challenging because ear cartilage has few blood vessels and limited regenerative capacity. Traditional methods that utilize autologous costal cartilage or synthetic polymers often lead to donor site morbidity and suboptimal biocompatibility. In this study, we introduce 3D-printed scaffolds composed of decellularized human cartilage-derived bioink combined with polycaprolactone (PCL), designed to enhance both tissue regeneration and mechanical stability. The decellularization process effectively removed cellular components while preserving glycosaminoglycan and total collagen, comparable to those in native cartilage. We formulated the bioink by incorporating decellularized human cartilage particles into hyaluronic acid and carboxymethyl cellulose gels, optimizing the rheological properties for 3D printing. In vitro tests demonstrated that the decellularized human cartilage-derived bioink exhibited no cytotoxicity and facilitated the migration and chondrogenic differentiation of human adipose-derived stem cells. We fabricated 3D-printed scaffolds using this bioink combined with PCL and evaluated their performance in rabbits over a one-year implantation period. Our results indicated that the scaffolds maintained structural integrity throughout the year and exhibited significant neovascularization and chondrogenesis. Histological analysis revealed
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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