453 Biological responses to non-coated and coated steroidal implants containing equal doses and ratios of trenbolone acetate and estradiol benzoate in beef steers
Smith Z., Baggerman J., Kim J., Wellmann K., Johnson B.
Laboratory Study with a reported sample of 24, published in J Anim Sci (2018) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Anim Sci (2018)
- Reported sample size
- 24
- Source database
- Europe PMC
- PMCID
- PMC6285331
Abstract (original English)
Abstract Predominately Angus steers (n = 24; initial BW = 435 ± 28.3 kg) were used to evaluate non-coated and coated implants containing equal amounts of trenbolone acetate (TBA; 200 mg) and estradiol benzoate (EB; 28 mg) in finishing steers. Treatments were no implant (NI), non-coated (NC; Synovex-PLUS; Zoetis, Parsippany, NJ) and coated (CI; Synovex-One Feedlot) implant. There were 2 pen replicates per treatment (n = 4 steers/pen). Longissimus (LM) biopsies, blood, and BW were collected before feeding on d 0, 14, 28, 56, 84, 112, and 133. Androgen receptor (AR), estrogen receptor-α (ER-α), G-protein coupled receptor 30 (GPR30), IGF-I, and IGF-I receptor (IGF-IR) mRNA expression in LM was determined by RT-qPCR using two housekeeping genes. Sera was analyzed for estradiol-17β (E2), IGF-I, 17β-trenbolone (TbOH), and urea-N (SUN). Data were analyzed as repeated measures for a completely randomized design; α of 0.10 determined significance. No implant × day interaction was detected (P ≥ 0.20) for any genes. Coated implant increased (P 0.10; 0.24, 0.28, and 0.34 ± 0.020 arbitrary units for NI, NC, and CI, respectively). An implant × day interaction (P ≤ 0.10) for E2, IGF-I, and SUN was detected; implants elevated (P ≤ 0.10) E2, IGF-I and decreased SUN. Differing payout characteristics did not influence AR, ER-α or IGF-IR. Coated implants altered GPR30; increasing IGF-I in LM that i
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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