AB103. Overexpression of RNF2 is an independent predictor of outcome in patients with urothelial carcinoma of the bladder underwent radical cystectomy
Prospective Study with a reported sample of 184, published in Transl Androl Urol (2016) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Transl Androl Urol (2016)
- Reported sample size
- 184
- Source database
- Europe PMC
- PMCID
- PMC4842528
Abstract (original English)
Objective RNF2 is frequently overexpressed in several types of human cancer, but the status of RNF2 amplification and expression in urothelial carcinoma of the bladder (UCB) and its clinical/prognostic significance is unclear. Methods In this study, the methods of immunohistochemistry and fluorescence in situ hybridization (FISH) were utilized to examine the protein expression and amplification of RNF2 in 184 patients of with UCBs who underwent radical cystectomy. Results Overexpression of RNF2 was found in 44.0% of UCBs. A highly significant association between overexpression of RNF2 with shortened patient overall and cancer specific survival (P Conclusions our findings suggested that overexpression of RNF2, as examined by immunohistochemistry, might serve as a novel prognostic biomarker and potential therapeutic target for UCB patients treated with radical cystectomy.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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