AB157. The correlation between nNOS positive small branches of dorsal penis nerve and erectile function in bilateral cavernous nerve crush model of rat
Animal Study, published in Transl Androl Urol (2014) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Transl Androl Urol (2014)
- Reported sample size
- —
- Source database
- Europe PMC
- PMCID
- PMC4708439
Abstract (original English)
Purpose Cadavers’ evidences showed cavernous nerve (CN), a parasympathetic nerve, joint dorsal penis nerve (DPN) in the penis level. However, no reports elucidate the importance of the main or the small branches of the DPN in this model. The aim of the current study is to evaluate the association between nNOS positive small branches of DPN and erectile function in rat model. Materials and methods Totally, 20 SD male rats were divided into five groups: the sham group and BCNC in 7, 14, 21 and 28 days. Erectile function was assessed by CN electrostimulation, and penile tissue was collected for histology. Immunohistochemical stains for the confirmation of nerve types were done. Finally, transmission electron microscopy (TEM) for Schwann cell damage and other detailed morphological changes were also performed. Results Erectile function was significantly decreased in injury group with the lowest after 14 days of BCNC. Partial recovery of the erectile function was noted within the next 14 days. In H&E stain, mean diameter, number of neuritis, inflammatory cells infiltration of the largest branch of DPN were similar in both sham group and injury group after different days of observation. No correlation was seen in the total number of nerve branches, sympathetic nerve branches and erectile function. However, nNOS positive small branches, parasympathetic nerve branches, showed significa
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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