AB159. BDNF-hyper secreting human umbilical cord blood mesenchymal stem cells promote erectile function in a rat model of cavernous nerve electrocautery injury
Animal Study with a reported sample of 6, published in Transl Androl Urol (2014) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Transl Androl Urol (2014)
- Reported sample size
- 6
- Source database
- Europe PMC
- PMCID
- PMC4708390
Abstract (original English)
Introduction Erectile dysfunction (ED) continues to be a significant problem for men following radical prostatectomy. Aim To test the hypothesis that intracavernous injection of BDNF-hyper secreting human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) can ameliorate ED in a rat model of cavernous nerve electrocautery injury (CNEI). Methods Forty-two male Sprague-Dawley rats were randomly divided into four groups. Group A: sham operation rats intracavernosally injected with PBS (n=6); group B: CNEI rats intracavernosally injected with PBS (n=12); group C: CNEI rats intracavernosally injected with hUCB-MSCs (n=12); group D: CNEI rats intracavernosally injected with BDNF-hUCB-MSCs (n=12). Main outcome measures At week 4, the rats in each group underwent electrostimulation of the cavernous nerves to assess erectile function. Penile tissues were collected for histological examinations (Masson’s trichrome; immunofluorescence for S-100 and α-SMA; TUNEL assay). Transmission electron microscopy (TEM) was used to examine the CN distal to the site of injury. Results Four weeks after injection, rats which received BDNF-hUCB-MSCs showed the most significant improvement in the ratio of maximal ICP to MAP (ICP/MAP) compared with both the CNEI + hUCB-MSCs and CNEI + PBS animals (P Conclusions Intracavernous injection of BDNF-hyper secreting hUCB-MSCs can enhance the recovery of erecti
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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