AB75. Lower urinary tract dysfunction in a pink1 gene knockout rat model for Parkinson’s disease

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Bladder dysfunction is a common non-motor disorder on Parkinson’s disease (PD) patients. A new transgenic Pink1 gene knockout rat model of PD has been developed recently. To explore lower urinary tract function in this newly established PD model and provide possible therapeutic base for PD urinary complications. Twelve Pink1 KO rats (pink1-/-, LEH-pink1tm 1sage, 40 weeks old) and twelve wide type rats (pink1+/+, LEH, 40 weeks old) were used in this project. After acclimation, the rats underwent 24 hours metabolic cage test, conscious cystometry, and leak point pressure test. Their bladders were harvested, weighted and then fixed for histological study. Total volume, micturition times, and voided volume per micturition were calculated for 24h metabolic cage test. Pressure parameters, micturition frequency, bladder capacity/compliance, volume parameters, leak point pressure (LPP) were analyzed according to the result of cystometry and LPP test. Body weight, bladder weight, and the general pathologic changes in bladder were also checked. Continuous variables were compared between groups using t-test. Categorical variables were compared using Chi-square test. P<0.05 was set as statistical significant. Pink1 KO rats acquired the functional disorder of detrusor over activity compared to wild type rats. Hyperplasia of smooth muscle and nerves were noted in the bladder wall of Pink1 KO

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.