Ablation of UCP-1+ cells impacts FAP dynamics in muscle regeneration.
Parson JC., Meyer GA.
Animal Study, published in Am J Physiol Cell Physiol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Am J Physiol Cell Physiol (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40720154
- DOI
- 10.1152/ajpcell.00249.2025
Abstract (original English)
Uncoupling protein-1 (UCP-1+) cells found in brown adipose tissue and subtypes of white (a.k.a. beige) adipose tissue have been a focus of intensive investigation for their role in energy metabolism and are emerging as potential endocrine regulators of physiology. More recently, UCP-1+ subpopulations have also been found in skeletal muscle fibro-adipogenic progenitors (FAPs), which play an important role in regeneration. Both UCP-1+ adipocytes and FAPs secrete promyogenic cytokines further supporting their potential for proregenerative signaling. To investigate whether signaling from UCP-1+ cells does indeed promote regeneration, we examined injury-induced muscle regeneration in a mouse model with constitutive UCP-1+ cell ablation (UCP1-DTA) at three time points: early [3 and 7 days post injury (dpi)], intermediate (14 dpi), and late (21 dpi). We hypothesized that without UCP-1+ cells, muscle regeneration would be impaired at all time points. At 3 and 7 dpi, we found significantly reduced numbers of FAPs in male UCP1-DTA mice, but with no accompanying changes in muscle-derived stem (satellite) cells or immune cells. However, at 14 dpi, we observed significantly higher numbers of FAP in male UCP1-DTA mice and evidence of ongoing early-phase regeneration, including significantly increased histological and gene expression of early regenerative markers and significantly smaller reg
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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