An adipo-osteoprogenitor population in the endosteal niche contributes to bone and fat formation in adult mouse bone marrow.
Liao X., Koehnken Sawall J., Seeley R., Song F., Ji X., Liu X.
Animal Study, published in Proc Natl Acad Sci U S A (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Proc Natl Acad Sci U S A (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41248279
- DOI
- 10.1073/pnas.2502436122
Abstract (original English)
The adult bone marrow houses progenitors for both osteoblasts and adipocytes, but their precise molecular identity remains to be fully elucidated. Previous studies indicate that Lepr + Cxcl12 + bone marrow stromal cells collectively give rise to both osteoblasts and marrow adipocytes, but the high degree of heterogeneity among those cells calls for further delineation of common or lineage-specific progenitors in vivo. Here, by single-cell RNA-sequencing we identify a small subset of bone marrow stromal cells coexpressing Adipoq and Osx, along with other osteogenic or adipogenic genes. The Adipoq + Osx + cells predominantly reside in the endosteal niche. Intersectional genetic fate mapping with Dre and Cre recombinases demonstrates dual differentiation of osteoblasts and adipocytes from the Adipoq + Osx + cells in vivo. The data support the Adipoq + Osx + cells as adipo-osteoprogenitors contributing to bone and fat formation in the adult mouse bone marrow.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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