Adipose-derived mechanically processed tissue in orthopedics: A call for a standard classification system.
Sussman WI., Boettcher BJ., Kruse RC., Mautner K., Rogers CJ., Bowers RL.
Narrative Review, published in PM R (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- PM R (2026)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41918144
- DOI
- 10.1002/pmrj.70128
Abstract (original English)
Adipose-derived cellular therapies (AD-CTs) are increasingly used in orthopedics, yet the field lacks a standardized framework for classifying these heterogeneous products. Although prior efforts have standardized platelet-rich plasma and bone marrow-derived mesenchymal stromal cells, AD preparations remain inconsistently defined and poorly characterized. AD-CTs encompass a range of products including enzymatically derived stromal vascular fraction, culture-expanded adipose-derived mesenchymal stromal cells (AD-MSCs), and mechanically processed adipose tissue (AD-MPT),each with distinct regulatory, cellular, and structural profiles. Unlike stromal vascular fraction and AD-MSCs, which can be quantified using conventional assays, the intact extracellular matrix in AD-MPTs complicates objective characterization. This paper introduces the Mechanical Processing (Harvesting) of Adipose Tissue classification system as a novel framework for standardizing the reporting of AD-MPT harvesting and processing techniques that provides a structured approach to nomenclature and reporting. The system aims to enhance study comparability, facilitate research replication, and support the responsible advancement of adipose-based therapies in musculoskeletal medicine.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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