Adipose-derived stem cells alleviate radiation-induced muscle fibrosis by promoting muscle regeneration.
Li S., Peng M., Ou X., Zhou Z., Xie L., Ge Y.
Randomized Controlled Trial with a reported sample of 6, published in Front Cell Dev Biol (2025) — summary generated from the PubMed abstract.
Several human studies show positive signals, while research methods and sample sizes continue to develop.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Randomized Controlled Trial
- Journal
- Front Cell Dev Biol (2025)
- Country
- Switzerland
- Reported sample size
- 6
- Source database
- PubMed
- PMID
- 41210252
- PMCID
- PMC12592055
- DOI
- 10.3389/fcell.2025.1620998
Abstract (original English)
Background Radiation-induced muscle fibrosis (RIF) is a severe late-stage side effect of radiotherapy in adjacent normal tissues, significantly affecting anticancer therapeutic efficacy and potentially being life-threatening. Previous studies have shown that satellite cells (SCs) become activated after ionizing radiation to facilitate muscle tissue repair. However, the acceleration and strengthening of this process have received little attention until recently. Adipose-derived stem cells (ADSCs), a type of mesenchymal stem cell, have emerged as a promising therapeutic option in regenerative medicine due to their accessibility, abundance, and plasticity in adult organisms. In this study, we explored whether ADSCs could enhance SC proliferation and differentiation after radiation therapy. Methods ADSCs were harvested, cultured, and passaged from male Sprague-Dawley rats and characterized in vitro . In vivo , rats were randomly assigned to control and ADSC-treated groups (n = 6). ADSCs were transplanted into RIF rat models at different time points (4, 12, and 24 w). The therapeutic effects of transplanted ADSCs were assessed via Masson's trichrome staining, electron microscopy, and hematoxylin-eosin (H&E) staining. SC activation, proliferation, and central nuclear immigration following ADSC transplantation therapy were evaluated via real-time polymerase chain reaction and H&E stai
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Several human studies show positive signals, while research methods and sample sizes continue to develop.
How we grade evidenceBrowse all related research
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