SVF
Level A· Stronger Clinical EvidenceSystematic Review

Adipose-derived stem cells applied to ankle pathologies: a systematic review.

Arceri A., Mazzotti A., Artioli E., Zielli SO., Barile F., Manzetti M.

Systematic Review on Osteoarthritis, Cartilage Damage, Ankle Injury, Scar, published in Musculoskelet Surg (2024) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Musculoskelet Surg (2024)
Country
Italy
Reported sample size
—
PMID
37943411
DOI
10.1007/s12306-023-00798-7

Abstract (original English)

The purpose of this systematic review was to analyze the current use of adipose-derived mesenchymal stem cells (ADMSCs) and present the available evidence on their therapeutic potential in the treatment of ankle orthopedic issues, evaluating the applications and results. A literature search of PubMed, Google Scholar, EMBASE and Cochrane Library database was performed. The review was conducted following PRISMA guidelines. Risk of bias assessment was conducted through the Methodological Index for Non-Randomized Studies (MINORS) criteria. Initial search results yielded 4348 articles. A total of 8 articles were included in the review process. No clinical evidence has demonstrated the effectiveness of one isolation method over the other, but nonenzymatic mechanical method has more advantages. In all studies included significant clinical outcomes improvement were recorded in patients affected by osteochondral lesion and osteoarthritis of ankle. All studies performed a concomitant procedure. No serious complications were reported. ADMSC injection, especially through the nonenzymatic mechanical methods, looks to be simple and promising treatment for osteochondral lesions and osteoarthritis of the ankle, with no severe complications. The current scarcity of studies and their low-quality level preclude definitive conclusions presently. LEVEL OF EVIDENCE: III.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
HumansAdipose TissueAnkle JointMesenchymal Stem Cell TransplantationOsteoarthritisTreatment Outcome
Ankle & FootOsteoarthritisCartilage DamageAnkle InjuryScar
View on PubMedDOI

Related research