Adipose-Derived Stem Cells for Cartilage Tissue Engineering: A Bibliometric Analysis of Trends and Themes.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Purpose Adipose-derived stem cells (ADSCs) have shown great potential in cartilage tissue engineering (TE) due to their accessibility, high proliferation rate, and chondrogenic differentiation capacity. This study aims to systematically evaluate research trends, collaboration patterns, and emerging themes in ADSC-based cartilage TE through a bibliometric analysis, providing actionable insights to address knowledge gaps and advance the field. Patients and methods A systematic search was conducted on the Web of Science Core Collection (WoSCC) database to identify publications related to ADSCs and cartilage TE. Bibliometric and visualized analysis was performed using VOSviewers (V 1.6.20), CiteSpace (V 6.3.R1) and Bibliometrix (R 4.3.3). Results A total of 436 English articles were analyzed, involving 2356 authors from 1532 institutions across 50 countries/regions, contributing to 189 journals. The annual growth rate of publications was 8.73%, peaking in 2021. China contributed the most articles (n=127, 29.1%), followed by the USA (n=65, 14.9%). Leading institutions included Kaohsiung Medical University and Duke University. Tissue Engineering Part A had the highest H-index (21) and the most publications (n = 26). Reis Rui L. and Gomes Manuela E. were among the most influential contributors. Keyword analysis revealed an early focus on "in-vitro" studies and "bone-marrow", which lat

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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