SVF
Level D· Preclinical EvidenceLaboratory Study

Adipose-Derived Stem Cells From Human Lumbar Subcutaneous Tissue in Obesity: Inflammatory Microenvironment Promotes Differentiation Capacity.

Zhang Y., Yu S., Chen Y., Gao Y., Ma X.

Laboratory Study on Face & Skin, Back & Spine, published in Stem Cells Int (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Laboratory Study
Journal
Stem Cells Int (2026)
Country
United States
Reported sample size
—
PMID
42112496
DOI
10.1155/sci/2552466

Abstract (original English)

Adipose-derived stem cells (ADSCs), possessing multipotent differentiation potential, hold considerable promise for clinical stem cell therapy applications. ADSCs isolated from obese individuals may exhibit differences compared to those derived from individuals of normal weight. Adipose tissues were collected from donors with body mass index (BMI) values within the standard range (Group N) and the obese range (Group O), respectively. ADSCs were isolated from these tissues. The proliferative capacity, phenotypic characteristics, and functional properties of the derived ADSCs were comparatively assessed. To mimic the inflammatory microenvironment of adipose tissue in obese individuals in vitro, ADSCs from Group N were prestimulated with inflammatory cytokines and designated as Group Pre, followed by assessment of their phenotypic characteristics and functional properties. Proteomic analysis was performed on the conditioned medium collected from the ADSCs cultures. ADSCs of Group N exhibited stronger proliferation capacity than Group O. However, Group N demonstrated lower adipogenic and osteogenic differentiation potential compared to Group O, along with reduced expression of stemness-associated surface markers and genes. Compared to Group N, Group Pre showed no significant change in proliferative capacity; however, it exhibited enhanced adipogenic and osteogenic potential. Both t

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
Face & SkinBack & Spine
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