Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction
Song Y., Xing H., Luo Y., Li B., Li Y., Dong Z.
Narrative Review, published in Immun Ageing (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Immun Ageing (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41272743
- PMCID
- PMC12639662
- DOI
- 10.1186/s12979-025-00545-5
- Citations
- 2
Abstract (original English)
Aging has profound effects on whole-body homeostasis. With age, adipose tissue undergoes marked alterations in immune microenvironment and distribution as well as a loss of immune and metabolic capacities. Immune cells and adipokines constitute the immune microenvironment of adipose tissue. Chronic low-grade inflammation is one of the prominent features of aged adipose tissue. Age-related inflammation not only disrupts adipose tissue homeostasis but also interferes with its metabolic functions, promoting the development of age-related diseases. Here, we summarize the age-related alterations of adipose tissue, highlight the immune landscape, and discuss the mechanisms by which immune cells and adipokines affect age-related adipose tissue dysfunction. We also outline therapeutic strategies targeting adipose tissue inflammation, aiming to improve adipose tissue function and promote healthy aging.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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