Adipose tissue engineering from human adult stem cells: clinical implications in plastic and reconstructive surgery.
Stosich MS., Mao JJ.
Laboratory Study with a reported sample of 6, published in Plast Reconstr Surg (2007) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Plast Reconstr Surg (2007)
- Country
- United States
- Reported sample size
- 6
- Source database
- PubMed
- PMID
- 17255658
- DOI
- 10.1097/01.prs.0000244840.80661.e7
Abstract (original English)
Despite certain levels of clinical efficacy, current autografts and synthetic materials for soft-tissue reconstruction and/or augmentation suffer from donor-site morbidity, rupture, dislocation, and volume reduction. Human adult stem cells can self-replicate and differentiate into adipogenic cells in response to appropriate signaling cues. This study investigated the shape and dimension maintenance of engineered adipose tissue from adult human mesenchymal stem cells. Human mesenchymal stem cells were isolated from bone marrow of a healthy donor and differentiated into adipogenic cells. Adipocytes derived from these cells were encapsulated in a poly(ethylene glycol)-based hydrogel shaped into a generic cylinder (n = 6 implants), with hydrogel encapsulating human mesenchymal stem cells (n = 6) and cell-free hydrogel (n = 6) as controls. Porous collagen sponges were also used to seed human mesenchymal stem cell-derived adipocytes (n = 6), human mesenchymal stem cells (n = 4), or without cells (n = 4). All poly(ethylene glycol) and collagen constructs were implanted subcutaneously in athymic mice for 4 weeks. In vivo grafts demonstrated the formation of substantial adipose tissue encapsulating human mesenchymal stem cell-derived adipogenic cells in either poly(ethylene glycol)-based hydrogel or collagen sponge and a lack of adipose tissue formation in cell-free or human mesenchymal
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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