Adipose-Tissue Macrophage Diversity and Functions.
Grenet S., Ivanov S., Chinetti G.
Narrative Review, published in Int J Mol Sci (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Int J Mol Sci (2026)
- Country
- Switzerland
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41751896
- DOI
- 10.3390/ijms27041759
Abstract (original English)
Macrophages are the predominant immune cell type found in adipose tissue (AT). They play a critical role in tissue homeostasis and participate in metabolic regulation. In white adipose tissue (WAT), studies show that multiple macrophage subsets co-exist in the very same microenvironment. Yet these cells express selective membrane markers, allowing for identifying several well-distinguished populations. In the present review we discuss the diversity and functions of white-adipose-tissue macrophages. We summarize current knowledge regarding the intratissue distribution of macrophage populations and their specific association with stromal cells and discuss the mechanisms governing adipose-tissue macrophage generation and survival. We emphasize the central role of adipose-tissue macrophages in handling local lipid levels. A particular focus is placed on the recently described population of lipid-associated macrophages (LAMs), particularly abundant in adipose tissue during obesity development.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.