Adipose tissue releases nucleosides

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

It remains unclear how excess adipose tissue in obesity leads to inflammation, insulin resistance, and other comorbidities. Extracellular nucleosides can induce inflammation through the activation of immune cell toll-like and purinergic receptors. The present study quantified nucleoside release from adipocytes and adipose tissue. Cultured mouse adipocytes released many nucleosides used in RNA/DNA. Adipose tissue from obese mice released more nucleosides than that from control nonobese mice ex vivo and had higher interstitial fluid concentrations in vivo. Consistent with the mouse study, human adipose tissue also showed significant release of adenosine/deoxyadenosine, guanosine/deoxyguanosine, and uridine ex vivo. Adipocytes release nucleosides in part through the equilibrative nucleoside transporter 1, though other pathways also appear to contribute to extracellular nucleoside concentrations. Extracellular nucleosides induce adipose tissue expression of inflammatory cytokines Tnfα , Il6 , and Il1β . These data uncover a previously unknown phenomenon of adipocyte release of nucleosides, which contribute to adipose tissue inflammation in obesity. NEW & NOTEWORTHY Adipose tissue inflammation contributes to the morbidity and mortality of obesity. Adipocytes are known to release uridine and adenosine, but information on other nucleosides is lacking. As nucleosides can induce inflamm

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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