Advancements in Stem Cell Therapy for Managing Drug-Resistant Epilepsy.
Hamed M.
Narrative Review, published in Mol Neurobiol (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Mol Neurobiol (2026)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41721999
- DOI
- 10.1007/s12035-026-05753-8
Abstract (original English)
Epilepsy is a common chronic disorder of the nervous system and it is typically characterized by repeated seizures that arise from dysregulated electrical activity in the brain. Even with widely used antiseizure drugs and the option of surgery in selected cases, roughly 20 to 30% of patients go on to develop drug-resistant epilepsy, with persistent seizures that are often accompanied by neuronal damage, oxidative stress, and signs of mitochondrial dysfunction. In this context, stem cell therapy has drawn strong interest as a possible therapeutic direction, largely because multiple stem cell populations carry regenerative and neuroprotective potential, including embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), induced pluripotent stem cells (iPSCs), and adipose-derived regenerative cells (ADRCs). Evidence from animal studies and early clinical work suggests that transplantation approaches might support restoration of inhibitory neuronal networks, tone down neuroinflammatory signaling, and promote broader repair processes within injured circuits, which together could contribute to more durable seizure control. This review highlights recent advances in stem cell-based strategies for epilepsy, with attention to proposed mechanisms, reported therapeutic effects, and the animal models most often used to test these ideas. We also consider related r
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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