Advances in erectile dysfunction treatment research: a narrative review
Yao WJ., Dong JT., Jiang TP., Nie JN.
Narrative Review, published in Transl Androl Urol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Transl Androl Urol (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40800084
- PMCID
- PMC12336725
- DOI
- 10.21037/tau-2025-193
- Citations
- 3
Abstract (original English)
Background and objective Erectile dysfunction (ED) is one of the common diseases in middle-aged and older men, and its etiology mainly includes vascular diseases, neurological diseases, metabolic disorders, and psychological factors. This review takes the physiological mechanisms of penile erection as a starting point and provides an in-depth look at the major current treatments, which include phosphodiesterase type 5 (PDE5) inhibitors, gene therapy techniques, low-intensity extracorporeal shock wave therapy (Li-ESWT), low-intensity pulsed ultrasound therapy (LIPUS), and psychological treatments. The review further provides a critical analysis and summary of the advantages and limitations associated with each treatment approach. Finally, the article discusses the future directions of ED treatment, emphasizing the importance of integrating personalized and precision medicine principles into treatment planning to identify the most appropriate therapeutic strategy for each patient. Methods We conducted literature searches on academic platforms such as PubMed, Google Scholar, and Web of Science using the terms "erectile dysfunction", "stem cells", "low-intensity extracorporeal shock wave", "low-intensity pulsed ultrasound", "PDE5 inhibitors", "gene therapy", "penile prosthesis implantation", and "psychosexual therapy" collecting literature published from January 1990 to October 202
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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