Advances in Fibrin-Based Bioprinting for Skin Tissue Regeneration: Exploring Design, and Innovative Approaches

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The field of tissue engineering and regenerative medicine has made significant progress, especially in the realm of biofabrication, aiming to create functional tissues and organs for transplantation, ultimately transforming medical treatments. Fibrin, a versatile and biocompatible biomaterial derived from the clotting cascade, has emerged as a crucial component in the development of bioinks for various tissue regeneration applications. This review explores the multifaceted role of fibrin-based bioinks in promoting tissue regeneration, with a specific focus on skin tissue engineering. We describe the properties and characteristics of fibrin as a biomaterial, its potential for promoting angiogenesis, and its compatibility with mechanical design considerations. By considering key findings and insights, we emphasize the potential of fibrin-based bioinks in innovating tissue engineering strategies. This review highlights the role of fibrin-based bioinks in advancing regenerative therapies and indicates a new era of tissue engineering applications.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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