Advances in Innovative Surgical Implant Manufacturing for Hernia Repair and Soft Tissue Reconstruction

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Abdominal wall hernias occur in a high percentage of the general population, making prosthetic hernia repair one of the most common surgical procedures. Despite the significant development of surgical techniques and the improvement of surgical meshes, complications still burden the health of patients, as well as the health system. The successful integration of the mesh plays a crucial role in the minimizing the complications associated with hernia meshes. Regenerative medicine focuses on the development of new treatments and applications to heal tissues and organs in order to restore their function. It uses scaffolds that provide physical support and a suitable environment for accelerating repair and proliferation and promoting the regeneration of damaged tissue. Platelet-rich plasma and stem cells are essential tools in regenerative medicine since they have shown efficacy in multiple fields. The main risk factor negatively affecting the survival of any cell type, including stem cells on a prosthetic material, is ischemia. Without the minimum required supply of oxygen, growth factors, and cytokines, it is impossible for cells to successfully proliferate and differentiate. The addition of PRP to a surgical mesh is hypothesized to increase neoangiogenesis in the area, acting as a reservoir of growth factors that will create the right conditions for the proliferation and different

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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