Advances in tissue engineering; a novel technology making use of an in vivo vascularized chamber.
Debels H.
Animal Study with a reported sample of 6, published in Acta Chir Belg (2015) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Acta Chir Belg (2015)
- Country
- England
- Reported sample size
- 6
- Source database
- PubMed
- PMID
- 26021942
- DOI
- 10.1080/00015458.2015.11681078
Abstract (original English)
Regenerative therapies aim to repair or replace damaged tissues. Clinical applications may vary from organ replacement, to breast reconstruction or limb regeneration. In growing 3-dimensional tissue constructs, access to a nourishing vascular network is essential. In rats, an arteriovenous loop was surgically established from the femoral vessels and positioned inside a perforated chamber in the groin. Chambers were filled with 2 ml Adipogel, a novel acellular tissue engineering gel -containing growth factors and polymers. Constructs were harvested at 6 and 12 weeks (n=6) and assessed for volume and histological content. The chambers filled with tissue to about half of their content. Histological assessment showed growth of different tissue types within the chamber; not only had a vascular network grown throughout the construct by 12 weeks, adipose, muscular and connective tissue was abundantly present as well. The grown tissue-types seemed to resemble surrounding groin tissue. This in vivo study makes use of a novel technology for tissue generation. In a surgically established vascularized chamber, spontaneous tissue growth within an acellular gel was achieved. Most likely, stem cells residing in adjacent tissues were driven to the chamber to form new tissue. With this technology, hope rises for a variety of novel patient-tailored therapies, such as organ regeneration or soft t
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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