Aligned electrospun porous P34HB/lecithin scaffold for bone tissue regeneration
Liu W., Wang P., Wang Z., Yang H., Yu G., Sui L.
Animal Study, published in Sci Rep (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Sci Rep (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42034765
- PMCID
- PMC13284310
- DOI
- 10.1038/s41598-026-49029-6
Abstract (original English)
Bone tissue engineering has emerged as a promising restorative strategy for bone regeneration, yet it remains challenging to develop an appropriate scaffold with optimal porous microstructure for bone repair. Unlike random fibrous scaffolds, the aligned nanofibrous structure could provide contact guidance for cell orientation and enhances mechanotransduction signaling. The purpose of this study was to investigate the effect of aligned electrospun poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) nanofibrous scaffold with lecithin on guided bone regeneration. In this study, aligned P34HB scaffold (PA group) and random P34HB scaffold (PR group) were fabricated via electrospinning with different speeds of rotating collector, respectively. And lecithin was coated on PA scaffolds (PA/L groups) by immersion method. The morphology, phase composition, and physical properties of these scaffolds were characterized. Meanwhile, cellular behaviors of bone marrow mesenchymal stem cells (BMSCs), including proliferation, adhesion, osteogenic differentiation, and related gene expression, were also investigated. Finally, a rat critical calvarial defect model was used to evaluate the biocompatibility and effect of these scaffolds on bone repair. The mean fiber diameters of PR and PA scaffolds were 893.0 ± 189.4 nm and 832.6 ± 193.1 nm, respectively. And Lecithin coating significantly reduced t
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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