Amine functionalized TiO 2 doped mesoporous bioactive glass coated curcumin infused 3d printed poly (L-lactic acid): A promising multifunctional scaffold with enhanced osteogenesis and tumour relapse inhibition character

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The two main clinical problems with post-operative metastatic bone disease are high death rate and a notable local recurrence rate. When diseased bone sections are removed from patients, they suffer from significant bone defects that cannot be repaired on their own, and therefore require a support mechanism via the incorporation of scaffolds. In such cases, multifunctional scaffolds are deemed to be an appropriate option with promising potential as bone substitutes and limit the recurrence of post-operative tumour cells. This can be achieved via constructing a multi-functional scaffold incorporated with therapeutic compounds that helps in the prevention of tumour recurrence and improved surface characteristics for achieving enhanced osteogenesis. In the current work, a multi-functional scaffold is constructed via coating of amine functionalized Titanium dioxide (TiO 2 ) doped mesoporous bioactive glass (MBG) on 3D printed curcumin infused PLA support. The influence of curcumin incorporation towards inhibiting the growth of osteosarcoma cells and surface coating for enhanced osteogenesis of adipose-derived mesenchymal stem cells (AD-MSCs) is investigated. In this study, MBG is doped with TiO 2 and surface grafted with amine groups to facilitate coating on 3D printed PLA and curcumin infused PLA surface via EDC-NHS carbodiimide chemistry. As revealed by FESEM analysis, the bioact

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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