Anisotropic Mesenchymal Stem Cell Sheet Composed of Adipose-Tissue- and Umbilical-Cord-Derived Mesenchymal Stem Cells.
Nagase K., Kuramochi H., Takahashi H.
Laboratory Study, published in Biol Pharm Bull (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Biol Pharm Bull (2025)
- Country
- Japan
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40721369
- DOI
- 10.1248/bpb.b25-00364
Abstract (original English)
Mesenchymal stem cell (MSC) sheet therapies are effective in treating intractable diseases. Aligned and oriented bone-marrow-derived MSC sheets have been developed using stripe-patterned thermoresponsive cell culture dishes to increase the effectiveness of MSC therapies compared with unaligned MSC sheets. However, adipose-tissue- and umbilical-cord-derived MSCs (ADMSCs and UCMSCs, respectively) have not yet been used for preparing aligned cell sheets. Therefore, we prepared aligned cell sheets comprising ADMSCs and UCMSCs. We produced a patterned cell culture dish by modifying polyacrylamide into a striped pattern on a commercially available poly(N-isopropylacrylamide)-modified dish. Aligned cell sheets comprising ADMSCs and UCMSCs were successfully prepared in these culture dishes.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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