The Anti-Aging Effects of Adipose-Derived Mesenchymal Stem Cell Exosomes on Skin and Their Potential for Personalized Skincare Applications.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Stem cell-derive exosomes have gained increasing attention in the skincare industry in recent years due to their multiple anti-aging benefits. However, differences in cell sources lead to significant heterogeneity in the composition of secreted exosomes, resulting in inconsistent biological effects. Moreover, the lack of standardized production protocols and the technical challenges associated with large-scale manufacturing continue to limit their broader application in the beauty industry. As a narrative review, this article systematically summarizes the biological functions and mechanisms of action of autologous adipose mesenchymal stem cell-derived exosomes (AMSCs-Exos) in anti-skin aging, covering in vitro, in vivo, and clinical studies. Recent studies have shown that autologous exosomes derived from AMSCs not only possess the common bioactivity shared by stem cell-derived exosomes but also exhibit higher biocompatibility and a lower risk of pathogen transmission. In addition, their suitability for small-scale production makes them a more advantageous option. Furthermore, advances in artificial intelligence (AI) technology are driving the transformation of the cosmetics industry from traditional skincare to personalized skincare: AI provides a basis for the personalized matching of exosome dosage and delivery methods through high-precision skin condition monitoring. It opti

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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