Anti-aging mechanism of different age donor-matched adipose-derived stem cells.
Wang T., Li Y., Zhu Y., Liu Z., Huang L., Zhao H.
Animal Study, published in Stem Cell Res Ther (2023) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Stem Cell Res Ther (2023)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 37533129
- PMCID
- PMC10394785
- DOI
- 10.1186/s13287-023-03415-3
- Citations
- 8
Abstract (original English)
Background Adipose-derived stem cells (ASCs) have anti-aging and anti-obesity effects in aged animals, but the underlying molecular mechanism remains unknown. Methods In the present study, we evaluated the in vivo transplantation effects of different age donor-matched ASCs on natural aging and leptin knockout mice (ob - /ob - mice). The multi-omics expression profiles of young and aged mouse donor-derived ASCs were also analyzed. Results The results revealed that ASCs from young donors induced weight and abdominal fat loss for older recipients but not for young or ob - /ob - mice. The young and aged mouse donor ASCs displayed significant phenotypic differences, contributing to the distinguished weight loss and anti-aging effects in aged mice. Conclusions Our data suggest an underlying molecular mechanism by which young-donor ASCs reduce immune cells and inflammation in aged mice via secreted immune factors. These findings point to a general anti-aging mechanism of stem cells, which may provide new insights into age-related disturbances of stem cell plasticity in healthy aging and age-related diseases.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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