The Application of Exosomes From Different Sources Loaded with Natural Small-Molecule Compounds in Disease
Zhang L., Shi C., Yan L., Zhang X., Ji X., Li L.
Narrative Review, published in Int J Nanomedicine (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Int J Nanomedicine (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41112945
- PMCID
- PMC12531312
- DOI
- 10.2147/ijn.s542641
- Citations
- 3
Abstract (original English)
Exosomes, as naturally derived nanoscale vesicles, possess inherent biological functions that make them highly efficient drug delivery vehicles. Their cellular origin dictates their bioactivity, targeting specificity, and regulatory effects, which are critical for therapeutic applications. Natural small-molecule compounds, despite their therapeutic potential, are often limited by poor solubility, instability, toxicity, and rapid clearance. Exosomes can overcome these limitations by enhancing drug stability, improving bioavailability, and enabling targeted delivery to disease sites, while also contributing therapeutic effects through their intrinsic biological properties. This review summarizes advances in the application of exosomes from diverse cellular sources for delivering natural compounds in the treatment of various diseases, and discusses the dual functional mechanisms of exosomes as both carriers and therapeutic agents, highlighting the advantages of integrating exosomes with natural small-molecule compounds. The review aims to explore novel strategies for improving the utilization of natural small-molecule compounds and to inspire new perspectives for the development of targeted nanomedicines in the future.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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