Application of induced pluripotent stem cells in the conservation of endangered animals

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The accelerating biodiversity crisis urgently demands innovative approaches that transcend traditional conservation strategies, which are often constrained by genetic bottlenecks and disease risks. Induced pluripotent stem cells (iPSCs) technology emerges as a transformative solution, enabling non-invasive genetic preservation and multi-pathway species recovery. This review synthesizes advances in reprogramming somatic cells from endangered species into iPSCs through integration-free strategies, such as mRNA, Sendai virus, episomal systems, adenoviruses and chemical induction, thereby reducing genomic instability. We highlight breakthroughs in differentiating iPSCs into functional gametes for assisted reproduction and blastoids formation for embryonic reconstruction, circumventing donor oocyte dependency and genetic homogeneity risks. Despite challenges in lineage specification and epigenetic fidelity, combining iPSC biobanking with ecosystem management enables large-scale genetic rescue. By combining these technologies with ethical frameworks and habitat restoration, the plasticity of cells may be transformed into population resilience, potentially redefining biodiversity conservation.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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