Application of infrapatellar fat pad-derived stem cells after surgical reconstruction of a ruptured cranial cruciate ligament in a dog.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Adipose-derived stem cells (ASCs) have been utilized in regenerative and anti-inflammatory therapies. Among the various sources of ASCs, infrapatellar fat pad-derived adipose stem cells (IFP-ASCs) have been proposed as an alternative source for treating orthopedic diseases in humans; however, their clinical application remains limited. Furthermore, clinical reports on the use of IFP-ASCs are scarce in veterinary medicine. The present report describes the first clinical application of IFP-ASCs in a dog following surgical reconstruction of a ruptured cranial cruciate ligament (CCL). After intra-articular injections of IFP-ASCs adjunctive to surgical stabilization, reductions in inflammatory cytokine levels and improvements in clinical orthopedic scores were observed without any adverse effects. This case suggests that autologous IFP-ASC treatment after surgical CCL reconstruction may be a safe and effective adjunctive treatment for canine joint disorders.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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