Level C· Early human research exploring benefitsProspective StudyPubMed

Application of Orbital Septal Fat Repositioning Combined With SVF-Gel Fillers in Lower Blepharoplasty.

Zhang H., Zhang Y., Lu Z., Qian J., Ye Z., Long X.

Prospective Study with a reported sample of 42 on Ligament Injury, Scar, published in J Craniofac Surg (2025) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Prospective Study
Journal
J Craniofac Surg (2025)
Country
United States
Reported sample size
42
Source database
PubMed
PMID
40146291
DOI
10.1097/SCS.0000000000011289
Citations
2

Abstract (original English)

Background Lower blepharoplasty is a widely used cosmetic surgical procedure to improve under-eye bags and tear trough deformities, aiming to enhance facial aesthetics and achieve a more youthful appearance. The formation of these deformities is often associated with factors such as aging, skin laxity, and fat displacement. Traditional surgical methods include orbital septal fat repositioning and fat grafting, each with its own advantages and limitations. Transconjunctival blepharoplasty avoids external incisions by performing the surgery through the conjunctiva, thereby reducing postoperative scarring and recovery time. However, orbital septal fat repositioning alone is often insufficient to completely address issues of inadequate orbital septal fat and lax tear trough ligaments. Therefore, a combined approach of orbital septal fat repositioning and SVF-gel injection has been proposed to achieve more lasting and satisfactory results. Objective This study aims to investigate the advantages and rationality of combining orbital septal fat repositioning with SVF-gel injection in lower blepharoplasty, to assess the improvement in tear trough deformities and lower eyelid skin quality, to define its indications, and to achieve personalized treatment. Methods This study involved 42 patients who underwent transconjunctival blepharoplasty combined with fat repositioning and SVF-gel inje

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

How we grade evidence
HumansBlepharoplastyFemaleMiddle AgedAdipose TissueAdultMaleDermal FillersOrbitGels

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