Level D· Scientific groundwork from lab and animal studiesLaboratory StudyEurope PMCOpen access

Application of polyetheretherketone temporal muscle prostheses for temporal hollowing following cranioplasty

Yang X., Zhang Y., Guan J.

Laboratory Study on Face & Skin, published in Front Neurol (2025) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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Study type
Laboratory Study
Journal
Front Neurol (2025)
Reported sample size
—
Source database
Europe PMC
PMID
41036270
PMCID
PMC12479287
DOI
10.3389/fneur.2025.1664624

Abstract (original English)

Background Decompressive craniectomy is an effective intervention for refractory intracranial hypertension. However, subsequent cranioplasty, though technically less demanding, is associated with a non-negligible incidence of complications. Among these, temporal hollowing is a common yet frequently overlooked sequela that significantly compromises facial aesthetics and can lead to various psychosocial issues. Methods Based on the pathophysiological mechanisms underlying temporal hollowing following cranioplasty and incorporating clinical experience from West China Hospital, Sichuan University, this study explores the application of 3D-printed polyetheretherketone (PEEK) temporal muscle prostheses for correcting temporal hollowing after 3D-printed PEEK cranioplasty. The approach involves precise measurement of the contralateral temporal muscle dimensions and volumetric assessment of the atrophied ipsilateral muscle to fabricate patient-specific 3D-printed PEEK implants. These customized prostheses are then surgically implanted in a secondary procedure to restore temporal contour symmetry. Conclusion Temporal hollowing represents a frequent sequela of cranioplasty, arising from multifactorial mechanisms and often contributing to psychosocial challenges. The patient-specific 3D-printed PEEK temporal muscle prosthesis, developed based on contralateral temporal muscle metrics at Wes

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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