Application of stem cells in the precise diagnosis and treatment of liver diseases

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Liver diseases caused by diverse inflammation or cancer have serious damaged people's physical and mental health and become a heavy social burden. Stem cells possess unique properties of self-renewal and multi-directional differentiation, which are widely used for disease remodeling and regenerative medicine. Of them, human induced pluripotent stem cell-based liver organoids with self-organization of sinusoidal vessels have been reported for diverse liver cancer remodeling and drug sensitivity test, which provide unique platforms to dissect functional consequences of diverse levels of heteroplasmy of target gene mutation in liver cancers. Meanwhile, mesenchymal stem/stromal cells have been adopted for clinical treatment research on various liver diseases, including acute liver injury, decompensated liver cirrhosis, hepatic fibrosis and acute-on-chronic liver failure. In this review article, we mainly focus on the state-of-the-art literatures upon stem cell-based disease modeling and cell therapy for multifarious liver diseases from the view of basic research and clinical progress, which will provide references for the development of stem cell-based regenerative medicine in the precise diagnosis and treatment of liver diseases.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.