SVF
Level A· Stronger Clinical EvidenceMeta-analysisPubMed

THE APPLICATION OF STEM CELLS IN TISSUE ENGINEERING FOR THE REGENERATION OF PERIODONTAL DEFECTS IN RANDOMIZED CONTROLLED TRIAL: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Zhang Y., Zhao W., Jia L., Xu N., Xiao Y., Li Q.

Meta-analysis with a reported sample of 87 on Ligament Injury, published in J Evid Based Dent Pract (2022) — summary generated from the PubMed abstract.

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Level A· Stronger Clinical EvidenceEvidence level of this study

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Meta-analysis
Journal
J Evid Based Dent Pract (2022)
Country
United States
Reported sample size
87
Source database
PubMed
PMID
35718427
DOI
10.1016/j.jebdp.2022.101713
Citations
14

Abstract (original English)

To systematically evaluate the application of stem cells in tissue engineering for regeneration of periodontal defects and to provide a basis for clinical application. PubMed, The Cochrane Library, EMbase, SinoMed, CNKI and Wanfang database were searched for randomized controlled trial (RCT) studies on periodontal defect regeneration using bone marrow mesenchymal stem cells, adipose tissue-derived stem cells, periodontal ligament stem cells (PDLSCs), dental pulp stem cells (DPSCs), gingival mesenchymal stem cells, stem cells from apical papilla and other odontogenic stem cells. Chinese and English literature as of May 9, 2021 (without limitation on retrieve starting date) were searched, and included RCT studies were followed for at least 3 months. Two reviewers independently screened the literature, extracted basic research information, the situation of the research object and outcome measures including probing depth (PD), clinical attachment level (CAL), bone defect depth (BDD) and gingival recession (GR). Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0) was used to evaluate bias risk in included studies and Meta-analysis was performed using RevMan 5.4 software. A total of 182 teeth were included in 7 RCT studies. The experimental group was treated with stem cell tissue engineering technology (87 cases), and the control group was treated with conventio

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
Alveolar Bone LossGingival RecessionGuided Tissue Regeneration, PeriodontalHumansPeriodontal Attachment LossRandomized Controlled Trials as TopicStem CellsTissue EngineeringTreatment Outcome
Ligament Injury
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