Artificial Intelligence-Guided Precision Orthobiologics in Musculoskeletal Conditions.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The use of orthobiologics such as autologous peripheral blood-derived orthobiologics, bone marrow-derived biologics, adipose tissue-derived biologics, mesenchymal stem cells, and extracellular vesicles is gaining traction in the field of orthobiology for the treatment of osteoarthritis (OA), tendinopathy, cartilage injuries, and delayed musculoskeletal healing. Clinical responses are inconsistent due to biological variation among patients, disease manifestations, product composition, delivery accuracy, and outcome definitions. The literature was searched in PubMed, Embase, Cochrane Library, and Scopus databases from January 2019 to June 2026, and landmark and regulatory concepts were considered. The search terms were orthobiologics, platelet-rich plasma, mesenchymal stromal cells, OA, tendinopathy, artificial intelligence (AI), machine learning, imaging biomarkers, ultrasound guidance, responder prediction, potency assays, software as a medical device and regulation. The synthesis of evidence was done in a narrative fashion based on the Scale for the Assessment of Narrative Review articles principles. AI has the greatest clinical relevance as an enabler for precision orthobiologics. Supervised models can predict responder probability after platelet-rich plasma; unsupervised clustering can identify inflammatory, metabolic, structural, or pain-dominant phenotypes; deep learning c

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.