Assessment of the Influence of Antisolvent 3D Printing Conditions on the Mechanical and Biological Properties of Poly(lactic-co-glycolic) Acid Scaffolds
Mironov AV., Trifanova EM., Bukharova TB., Vasilyev AV., Chernomyrdina VO., Nedorubova IA.
Laboratory Study, published in Polymers (Basel) (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Polymers (Basel) (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40006163
- PMCID
- PMC11859950
- DOI
- 10.3390/polym17040501
Abstract (original English)
This paper describes an evaluation of the mechanical and biological properties of highly porous, biocompatible poly(lactic-co-glycolic acid) (PLGA) scaffolds produced using the antisolvent 3D printing technique under various forming conditions. The dependence of the scaffolds' microstructure, PLGA molecular weight distribution, and cell adhesion properties on temperature and injection nozzle diameter was evaluated. All samples consisted of fibers with different inner polymer distributions formed by specific radial, highly porous structures with a mean pore length of less than 50 μm and a diameter below 10 μm. The microstructure formed using a nozzle with a diameter of 160 μm showed a moderate correlation with printing temperature, while for the 330 μm nozzle, there was no significant difference in microstructures formed at different temperatures. Scaffolds produced at lower temperatures of 4 °C with a thin nozzle showed better compression load characteristics in terms of strength. In contrast, a larger nozzle allowed the production of a PLGA structure with improved elasticity. A 10-17% change in the molecular weight of PLGA was observed during printing, but no influence on biological properties was found. All types of PLGA scaffolds tested demonstrated good biocompatibility and promoted cell adhesion compared to the control.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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