Atypical lipomatous tumor/well-differentiated liposarcoma in the subcostal space of the chest wall: a case report and review of the literature.
Cheng YL., Chen HL., Keong DE., Yue CT., Hsieh MS.
Case Report / Series, published in J Cardiothorac Surg (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Case Report / Series
- Journal
- J Cardiothorac Surg (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41437094
- DOI
- 10.1186/s13019-025-03695-1
Abstract (original English)
Atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDL) is a rare low-grade malignant tumor primarily composed of adipose tissue. Although lipomatous tumors commonly develop in the subcutaneous tissues, those originating from the chest wall are infrequently reported. Accurate diagnosis and appropriate treatment are essential, given the tumor's potential for local recurrence despite its low metastatic risk. We report the case of a 45-year-old man with a firm, enlarging, and painless mass in the left anterior lower chest wall. Imaging revealed a well-defined, fat-attenuated mass (4.8 × 5.0 × 5.2 cm) located in the left precardial subcostal space. Incisional biopsy suggested a lipomatous neoplasm. Thoracoscopic-assisted total removal excision was performed. Histopathological analysis showed mature adipose tissue with stromal cell atypia and muscle infiltration. Immunohistochemistry was negative for MDM2 and CDK4. Due to close microscopic margins and the tumor's deep location, adjuvant radiation therapy was administered. The final diagnosis was ALT. No recurrence was noted at the about 2-year follow-up, and the patient reported excellent postoperative quality of life. ALT of the chest wall is rare, and its management requires accurate diagnosis, complete resection, and consideration of adjuvant therapy when margins are close. This case contributes to the limited liter
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Without an adequate control group, treatment effects cannot be separated from other factors.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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