Autologous Fat Grafting Combined With Platelet-Rich Plasma in the Treatment of Female Genitourinary Aging: A Retrospective Study

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Female genitourinary aging (because of childbirth, menopause, weight changes, and aging) causes genital shrinking, vaginal laxity, dyspareunia, and urinary issues, impairing quality of life. Current treatments (lubricants, hormone creams, and laser) are temporary, have drawbacks, or lack clear guidelines. Autologous fat grafting (AFG) enables safe volumization, and platelet-rich plasma (PRP) promotes tissue repair, but evidence for their combination here is scarce. Objectives The aim of this study was to explore the clinical efficacy and safety of AFG combined with PRP in female external genitalia and vaginal rejuvenation. Methods A retrospective study included 38 patients (January 2020 to December 2024) with genital/vaginal aging who received combined AFG (mons pubis, labia majora, G-spot, and perineum) and PRP. Postoperative evaluations were performed with the Vaginal Laxity Questionnaire (VLQ) and the Female Sexual Function Index (FSFI), and complication monitoring was conducted. Results Postoperative VLQ scores rose from 2.45 ± 0.81 to 5.03 ± 1.15 ( P = .027). All 6 dimensions of the FSFI (sexual interest, sexual arousal, vaginal lubrication, orgasm, sexual satisfaction, and dyspareunia) and the total FSFI score also significantly improved (all P Conclusions In this small cohort with limited follow-up, AFG combined with PRP treatment appears to improve the extern

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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