Level C· Early human research exploring benefitsProspective StudyEurope PMCOpen access

Autologous Fat Grafting for Dark Circle Exacerbation Following Lower Eyelid Blepharoplasty

Su YS.

Prospective Study on Face & Skin, published in Plast Reconstr Surg Glob Open (2026) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Prospective Study
Journal
Plast Reconstr Surg Glob Open (2026)
Reported sample size
—
Source database
Europe PMC
PMID
41907080
PMCID
PMC13023773
DOI
10.1097/gox.0000000000007561
Citations
1

Abstract (original English)

Background Lower eyelid blepharoplasty (LLB) is a widely performed cosmetic procedure. Many studies have investigated its postoperative complications; however, most have focused on lower eyelid retraction and malposition, with little attention given to the exacerbation of dark circles. This study aims to analyze the mechanisms underlying this complication and to assess the feasibility and effectiveness of autologous fat grafting as a corrective approach. Methods Thirty-two patients who developed dark circle exacerbation following LLB underwent autologous fat grafting between May 2023 and May 2025. The procedures included micro-fat harvesting, purification, and precise injection into the infraorbital region to restore volume and alleviate dark circle severity. Patient-reported improvement in dark circles was assessed at the final follow-up visit using a 5-point Likert scale. Results Postoperative questionnaires showed that the mean dark circle improvement score was 4.19 ± 0.69. In addition, 93.7% of patients perceived improvement in the eyelid-cheek junction, and 68.7% observed improvement in the appearance of the pretarsal roll (aegyo-sal). Conclusions Autologous fat grafting seems to be a safe and effective approach for managing dark circle exacerbation following LLB, demonstrating high rates of patient-reported improvement. This technique offers a valuable therapeutic option

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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