Autologous Fat Grafting and Neurolysis for Treatment of Recalcitrant Carpal Tunnel Syndrome.
Gostelie OFE., Domela Nieuwenhuis I., Nanninga GL., Paulusma SB., van Dongen JA., van der Heijden BEPA.
Prospective Study with a reported sample of 29, published in J Hand Surg Am (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- J Hand Surg Am (2025)
- Country
- United States
- Reported sample size
- 29
- Source database
- PubMed
- PMID
- 41258834
- DOI
- 10.1016/j.jhsa.2025.08.018
Abstract (original English)
Purpose There is no consensus on the treatment for recalcitrant carpal tunnel syndrome (CTS), a problem caused mainly by fibrous perineural adhesions. Neurolysis is advised with or without the interposition of vascularized tissue, a labor-intensive process causing considerable donor site morbidity. Autologous fat grafting has less donor site morbidity, and adipose-derived stromal cells in adipose tissue might recover nerve damage and prevent adhesions. The authors hypothesized that neurolysis combined with autologous fat grafting improves symptoms and reduces CTS recurrence. Methods Carpal tunnel syndrome patients with a second to fifth recurrence underwent neurolysis combined with perineural fat grafting using autologous lipoaspirate (n = 29). The Boston Carpal Tunnel Questionnaire was administered before surgery and twice during follow-up. The minimal clinically important difference was calculated individually for the symptom severity scale (SSS) and functional status scale (FSS). To determine whether patients experienced recurrence or required additional surgery, follow-up data were collected up to 5 years after surgery (range: 3-9.5 years). Results The Boston Carpal Tunnel Questionnaire scores improved after surgery for 86% of the patients and remained stable during the follow-up. Accordingly, median (interquartile range) SSS and FSS scores decreased from 3.75 (2.75-4.38) t
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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