Level C· Early human research exploring benefitsProspective StudyPubMed

Autologous Fat Grafting for the Treatment of Structural Infraorbital Dark Circles.

Su YS., Huang YB., Huang ZB., Yang YF., Wu YM., Lu SR.

Prospective Study with a reported sample of 88 on Ligament Injury, published in Aesthetic Plast Surg (2025) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Prospective Study
Journal
Aesthetic Plast Surg (2025)
Country
United States
Reported sample size
88
Source database
PubMed
PMID
39929984
DOI
10.1007/s00266-025-04718-x

Abstract (original English)

Background Infraorbital dark circles have become a troubling issue for many young people, giving a tired and aged appearance. A significant portion of these dark circles is caused by structural deformities in the lower eyelid area. Many treatment methods have been introduced for the treatment of structural dark circles (SDC). Among the treatment options, autologous fat grafting appears to be an effective approach for treating SDC in young individuals. Methods This study evaluated patients with SDC who underwent autologous fat grafting between December 2021 and August 2023. The proposed technique involved a deep-level ligament releasing injection using micro-fat, while the superficial layer was treated with stromal vascular fraction gel extracted from the micro-fat. Results A total of 88 patients enrolled in the study had an average age of 25.4 ± 3.1 years. Throughout the follow-up period (averaging 11.2 months), notable improvements in SDC and tear trough deformity were maintained without any major complications. Patient satisfaction, as self-assessed post-procedure questionnaires, revealed that 40.9% were very satisfied, 56.8% were satisfied, and 2.3% were neutral regarding the outcomes. Conclusions The autologous fat grafting technique we proposed is both effective and reliable, offering high patient satisfaction with minimal risk of complications. Long-term results have prov

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

How we grade evidence
HumansFemaleAdultTransplantation, AutologousAdipose TissueMalePatient SatisfactionYoung AdultTreatment OutcomeBlepharoplasty

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