Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background The aging process of the face is characterized by dermal thinning, loss of elasticity, and wrinkle formation. Injection of autologous micrografts containing fibroblasts (Am-FBs) has emerged as a promising regenerative technique. Objectives This trial aims to assess the efficacy and safety of Am-FBs for facial rejuvenation. Methods A randomized, open-label, controlled study was conducted. Forty patients presenting with mild to moderate dermal thinning, reduced elasticity, and wrinkles were divided into two groups: a study group (SG; n = 20) that received Am-FBs treatment and a control group (CG; n = 20) treated with a hyaluronic acid (HA)-based skin booster. Both groups received treatment at baseline (T0), at one month (T1), and at three months (T2). Clinical outcomes were evaluated at T1, T2, T3 (6 months), and T4 (12 months) through patient and physician evaluations, the Wrinkle Severity Rating Scale (WSRS), and objective skin elasticity metrics. In vitro evaluation of the Am-FBs and immunophenotypic characterization of the nucleated cell population contained in the Am-FBs suspension was performed. Results At T4, the SG showed significantly greater improvements in wrinkle depth, skin elasticity, and WSRS score than the CG ( p p = 0.049), whereas patient self-assessments ranged from 9 to 5 ( p = 0.039). Patient satisfaction was higher in the SG. The in vitro analysis

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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