Award winner for outstanding research in the PhD category, 2014 Society for Biomaterials annual meeting and exposition, Denver, Colorado, April 16-19, 2014: Decellularized adipose matrix hydrogels stimulate in vivo neova
Adam Young D., Bajaj V., Christman KL.
Animal Study, published in J Biomed Mater Res A (2014) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Biomed Mater Res A (2014)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 24510423
- DOI
- 10.1002/jbm.a.35109
Abstract (original English)
Decellularization of tissues offers the ability to produce tissue-specific extracellular matrix (ECM) scaffolds that recreate many of the biochemical aspects of the tissue of interest. In this study, we describe the in vivo function of decellularized adipose ECM hydrogels for treating subcutaneous adipose deficits. Adipose ECM hydrogels were combined with either adipose-derived adult stem cells or a biocompatible cross-linker, injected subcutaneously into nude mice, and evaluated over the course of 1 month. These ECM hydrogels showed improved integration with the surrounding tissue in vivo compared to a clinical standard soft tissue filler, Juvederm, and stimulated neovascularization. More importantly, these adipose ECM hydrogels facilitated new adipose regeneration within the material at 1 month, a feature not seen with current clinical soft tissue fillers. These results contribute to the growing evidence that ECM-based materials are capable of stimulating subcutaneous adipose regeneration, suggesting that future soft tissue filler materials could incorporate ECM elements in order to restore function to adipose deficits instead of simply filling them with static materials.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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