The beneficial effects of adipose-derived stem cell and hydrogen sulfide donor sodium hydrogen sulfide combination therapy on erectile dysfunction in a rat model of radical prostatectomy.
Asker H., Sezen SF., Yilmaz-Oral D., Turkcan D., Elçi MP., Kirlangic OF.
Animal Study, published in Eur J Pharmacol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Eur J Pharmacol (2025)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40419134
- DOI
- 10.1016/j.ejphar.2025.177760
- Citations
- 2
Abstract (original English)
Radical prostatectomy can lead to nerve injury-related erectile dysfunction (ED). Hydrogen sulfide (H 2 S) is an endogenous gasotransmitter that has a role in erectile physiology. Adipose-derived stem cells (ADSCs) can serve as a valuable cell source for treating degenerative disorders. We aimed to determine the possible constructive effects of H 2 S donor, sodium hydrogen sulfide (NaHS), and transplantation of ADSCs per se and their combination treatment on bilateral cavernous nerve transection (CNT)-induced ED. Sprague-Dawley rats were divided into five groups: Sham-operated, CNT, CNT-treated with NaHS, CNT-treated with ADSCs and CNT-treated with NaHS and ADSCs groups. In vivo erectile responses, in vitro relaxant and contractile responses of corpus cavernosum were calculated. Protein expression and localization of nitric oxide synthases (NOS), H 2 S synthesis enzymes, fibrosis, and hypoxia markers as well as the smooth muscle/collagen ratio were analyzed. Rats with CNT exhibited significant decreases in erectile responses, acetylcholine and electrical field stimulation (EFS)-induced relaxation, phenylephrine and EFS-induced contractile responses of the corpus cavernosum, when were moderately increased by NaHS or ADSCs treatments alone. The combination therapy significantly improved the reduction. All treatment regimens improved decreases in NOS and H 2 S synthesis enzymes pr
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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