A Bibliometric Analysis of Exosomes Associated with Rheumatic Diseases in the 21st Century

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Purpose Numerous studies have suggested that exosomes are associated with rheumatic diseases, but no bibliometric analysis has been performed. This study presents the first comprehensive bibliometric analysis aiming to evaluate the current research hotspots and to anticipate future trends. Methods An electronic search was conducted in the Web of Science Core Collection (WOSCC) using exosome and rheumatic disease-specific terminology to identify eligible studies published from January 1, 2000 to October 19, 2024. Only English-language articles and review articles were selected for bibliometric analysis. Data analysis and visualization were conducted using CiteSpace 6.2.R3, VOSviewer 1.6.18, and the Bibliometrix R package. Results A total of 1,251 publications with 49,374 citations were extracted from the WOSCC database. Both publication and citation frequency increased steadily. 255 different countries or regions, 4,413 institutions and 7,213 authors contributed to the field. China and the USA are the leading countries and Shanghai Jiao Tong University has a significant influence. Théry C is the most frequently co-cited researcher. Most papers are published in Frontiers in Immunology, while Stem Cell Research & Therapy has the highest citations. Research is primarily concentrated in cell biology, immunology, and experimental medicine. Exosm, mesenchymal stem cells (MSCs), autoim

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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